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1. Scelsi R, Candura SM: [Occupational toxic neuropathies: morphology in peripheral nerve biopsies]. G Ital Med Lav Ergon; 2012 Oct-Dec;34(4):410-9
MedlinePlus Health Information. consumer health - Peripheral Nerve Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Occupational toxic neuropathies: morphology in peripheral nerve biopsies].
  • [Transliterated title] Neuropatie tossiche occupazionali: quadri morfologici in biopsie del nervo periferico.
  • Many peripheral neuropathies are caused by the (acute or chronic) toxic action of metals, solvents, pesticides, and other occupational and environmental contaminants.
  • These agents often reproduce the anatomoclinical pictures of hereditary (e.g., Charcot-Marie-Tooth disease), autoimmune (Guillain-Barrè syndrome), or dysmetabolic (thiamine deficiency, diabetic neuropathy) forms.
  • Toxic peripheral neuropathies can be classified on the basis of etiology, clinical features (sensitive, motor, sensitive-motor), or histopathology: neuronopathies (uncommon, mostly secondary to retrograde axonal degeneration; e.g., arsenic, thallium), axonopathies (acrylamide, esacarbons, CS2, organophosphate-induced delayed neuropathy), myelinopathies (trichloroethylene), mixed forms (axonal and demyelinating: lead).
  • Cessation of exposure is often followed by (microscopically observable) regenerative phenomena and clinical improvement.
  • The morphology of neuropathies can be studied through peripheral nerve biopsy.
  • Samples of sural nerve (or other nervous trunks of the limbs), adequately fixed, sectioned, and stained, allow the observation of alterations in axonal fibres (e.g., giant-axonal neuropathy, dying back neuropathy), myelin (demyelination), Schwann cells, interstitium, and blood vessels; possible inflammatory infiltrates; fibre density; regenerative phenomena (growth cone, remyelination).
  • In such cases, current optical and electron microscopy techniques can be very useful for injury evaluation, prognosis, and follow-up.
  • [MeSH-major] Biopsy. Occupational Diseases / chemically induced. Occupational Diseases / pathology. Peripheral Nervous System Diseases / chemically induced. Peripheral Nervous System Diseases / pathology. Sural Nerve / pathology

  • MedlinePlus Health Information. consumer health - Biopsy.
  • MedlinePlus Health Information. consumer health - Occupational Health.
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  • (PMID = 23477107.001).
  • [ISSN] 1592-7830
  • [Journal-full-title] Giornale italiano di medicina del lavoro ed ergonomia
  • [ISO-abbreviation] G Ital Med Lav Ergon
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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