Silver-loaded seaweed-based cellulosic fiber improves epidermal skin physiology in atopic dermatitis: safety assessment
, mode of action and controlled, randomized single-blinded exploratory in vivo study.
Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: skin
sensitisation. ... Characterisation of skin sensitisation potential is a key endpoint for the safety assessment
of cosmetic ingredients especially when significant dermal exposure to an ingredient is expected.9.
A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: skin
irritation. ... Evaluation of the skin irritancy and corrosivity potential of an ingredient is a necessity in the safety assessment
of cosmetic ingredients.10.
Combined with the data demonstrating little acute toxicity, no skin or ocular irritation, and no reproductive or developmental toxicity, these data form an adequate basis for reaching a conclusion that Dibutyl Adipate is safe as a cosmetic ingredient in the practices of use and concentrations as reflected in this safety assessment
The TEA is reported to function as a surfactant or pH adjuster; the related TEA-containing ingredients included in this safety assessment are reported to function as surfactants and hair- or skin
The data needed in order to complete the safety assessment of Cetethyl Morpholinium Ethosulfate include: methods of manufacture and impurities, especially nitrosamines; current concentration of use; skin penetration; if there is significant skin penetration, then both a 28-day dermal toxicity study to assess general skin
and systemic toxicity and a reproductive and developmental toxicity study are needed; two genotoxicity studies, at least one in a mammalian system, if positive, then a 2-year dermal carcinogenisis study using National Toxicology Program (NTP) methods may be needed; ultraviolet (UV) absorption data, if significantly absorbed, then photosensitization data are needed; dermal irritation and sensitization; and ocular toxicity, if available.18.
Pig/minipig is considered a good model for the safety assessment of DNA vaccines due to the similarity to human skin
A skin sensitization safety assessment
of a new bleach activator technology in detergent applications.